MULTIPLE

The UK Multiple Long-Term Conditions (MLTC) Research Registry

Identifying individuals with complex multiple long-term conditions and actively engaging them in clinical research, ensuring that the findings are truly relevant and applicable to those living with MLTC

People living with MLTC are underrepresented in research due to restrictive eligibility criteria, study designs that overlook their complex needs, and higher rates of adverse events leading to dropout.

The MULTIPLE Registry was developed to address this gap by identifying people with complex MLTC and supporting their inclusion in clinical studies.

The MULTIPLE Registry includes over 200 phenotyped individuals from across the UK who are living with MLTC and have expressed an interest in research. It supports studies that aim to improve understanding and treatment of ageing, sarcopenia and MLTC.

The MULTIPLE Registry recruits adults with four or more long-term conditions from across the UK, spanning primary, secondary, and tertiary care settings.

Baseline assessments are conducted in research clinics or participants’ homes and include physical and cognitive testing (Short Physical Performance Battery, Montreal Cognitive Assessment, Fried frailty score), the collection of routinely recorded health data, and monitoring of healthcare utilisation. Participants’ willingness to engage in future research is also recorded.

The registry helps to advance research into ageing, sarcopenia and MLTC by supporting recruitment to studies and providing data to answer research questions.

As of Autumn 2025, over 200 people have joined the registry, all of whom have given their consent to be approached for future studies. The registry is currently supporting recruitment to a number of clinical studies and providing detailed data on MLTC, healthcare use, and factors influencing participation. It also recruits participants into MULTIPLE STRiDE, a geroscience study that aims to uncover the biological drivers of symptoms like fatigue, low mood, muscle loss, and inactivity that many people with MLTC experience - aiming to reveal shared pathways and identify treatments that benefit people with a range of different long-term conditions.

Recruiting sites

Newcastle upon Tyne NHS Foundation Trust

Principal Investigator: Prof. Miles Witham
Research Nurse: Katie Sloan

South Tyneside &
Sunderland NHS
Foundation Trust

Principal Investigator: Dr Claire Morris
Sub-Investigator: Dr Fionnuala Johnston
Research Nurse: Madeleine Richardson

Gateshead Health NHS Foundation Trust

Principal Investigator: Dr Claire McDonald
Research Nurse: Bryony Storey

NHS Grampian Aberdeen

Principal Investigator: Prof. Roy Soiza
Research Nurse: Azeezat Ogunbadejo

Enquiries

If you are living with multiple long-term health conditions and you would like to learn more about joining the registry, please complete our Expression of Interest Form.

If you are a researcher seeking to use the registry for study recruitment or would like to access data for research purposes, please complete the Registry Access Enquiry Form and the Access Committee will consider your request